CJC-1295 (NO DAC) 10mg
CJC-1295 is a synthetic analog of growth hormone–releasing hormone (GHRH). It was developed to extend the half-life and potency of native GHRH while maintaining its ability to stimulate growth hormone (GH) release through pituitary activation. The NO DAC (without Drug Affinity Complex) version has a shorter half-life compared to DAC-modified CJC-1295, making it better suited for pulsatile GH release studies that mimic natural circadian secretion.
$69.99
Mechanism of Action
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Binds to GHRH receptors in the anterior pituitary.
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Stimulates pulsatile secretion of growth hormone.
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Indirectly increases IGF-1 production in the liver.
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Supports research into muscle growth, recovery, fat metabolism, and cellular repair.
Key Research Findings
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Promotes natural growth hormone pulses without continuous overstimulation.
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Supports lean body mass development and fat oxidation in preclinical studies.
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Demonstrated potential in studies of injury recovery, immune support, and healthy aging.
Specifications
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Form: Lyophilized peptide powder
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Purity: ≥ 98% (HPLC verified)
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Available Sizes: 5mg or 10mg vials
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Storage: Store at -20°C dry. Reconstituted solution should be refrigerated (2–8°C).
Intended Use
For laboratory research use only. Not for human consumption, medical, or veterinary use.
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CJC-1295 (NO DAC)
CJC-1295 is a synthetic growth hormone–releasing hormone (GHRH) analog designed to stimulate growth hormone (GH) release. Unlike the DAC-modified version, CJC-1295 NO DAC has a shorter half-life, making it useful in research on physiological, pulsatile GH secretion.
Growth Hormone Secretion & IGF-1
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CJC-1295 binds to GHRH receptors in the pituitary, triggering GH release and subsequent IGF-1 production in the liver.【1】
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Studies show increased GH pulse amplitude while maintaining natural circadian rhythm of secretion.【2】
Metabolism & Body Composition
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Research indicates improved nitrogen retention and lean muscle development in GH-deficient models.【3】
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CJC-1295 has been investigated for fat metabolism, with evidence suggesting enhanced lipolysis and fat oxidation.【4】
Recovery & Repair
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Elevated GH and IGF-1 levels may support tissue repair, immune function, and recovery after injury in preclinical settings.【5】
References
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Teichman, S. L., Neale, A., Lawrence, B., Gagnon, C., Castaigne, J. P., & Frohman, L. A. (2006). Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. Journal of Clinical Endocrinology & Metabolism, 91(3), 799–805. https://doi.org/10.1210/jc.2005-1536
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Frohman, L. A., & Kineman, R. D. (2002). Growth hormone-releasing hormone and pituitary development, hyperplasia and tumorigenesis. Trends in Endocrinology & Metabolism, 13(8), 299–303. https://doi.org/10.1016/S1043-2760(02)00628-5
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Veldhuis, J. D., & Bowers, C. Y. (2010). Human growth hormone (GH) pulsatility: an ensemble property regulated by age and gender. Endocrinology and Metabolism Clinics of North America, 39(1), 37–60. https://doi.org/10.1016/j.ecl.2009.10.001
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Giustina, A., & Veldhuis, J. D. (1998). Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocrine Reviews, 19(6), 717–797. https://doi.org/10.1210/edrv.19.6.0351
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Sonntag, W. E., Lynch, C. D., Cefalu, W. T., Ingram, R. L., Bennett, S. A., Thornton, P. L., & Khan, A. S. (1999). Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. Journal of Gerontology: Biological Sciences, 54A(12), B521–B538. https://doi.org/10.1093/gerona/54.12.B521
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